Worm zap Albendazole Tablet/Oral Suspension

 

Composition

Each chewable tablet contains:
Albendazole USP 400mg

Excipients

Each 10ml of suspension contains: Albendazole USP 200mg.

Suspension

Methyl paraben, propyl paraben, sorbitol, glycerin, sodium carboxymethyl cellulose, polysorbate, sodium saccharine, citric acid monohydrate, food flavor, purified water.

Tablet

Maize starch, lactose monohydrate, sodium saccharine, propyl paraben, talc, flavor, magnesium stearate, stearic acid.

Pharmacological Actions/Properties

Albendazole is an anthelminthic drug and acts by producing inhibitory effect on tubular polymerization, which results in the loss of cytoplasmic microtubules.

Indications

Albendazole is indicated in the treatment of single or mixed intestinal parasites. Clinical studies have shown to be effective in the treatment of Ascarislumbricoides (round worm), Trichuristrichiura (whipworm), Enterobiusvermicularis (pinworm/threadworm), Ancylostomaduodenale and Necatoramericanus (hookworm), Taenia spp. (tapeworm) and Strongyloidesstercoralis. Albendazole has been found to be effective in the treatment of gardai (duodenales or intestinalis or lamblia) infections in children.

Dosage and Administration

Adults and Children above 2 years: 20ml of Suspension as a single dose
1 tablet as a single dose.
Strongyloidiasis Taeniasis, H. nana infections: 20 ml of suspension or 1 tablet once daily for 3 consecutive days.

Hydatid disease

20ml of suspension or 1 tablet twice daily with meals for 28 days. The therapy may be repeated after 14 days interval for a total of 3 cycles.

Children (1-2 years) & Pregnant Women

Pregnant women and children below 2 years should consult a doctor before taking Worm zap.

SHAKE WELL BEFORE USE

Adverse Effects

Albendazole is generally well tolerated. However, adverse effects like nausea, vomiting, epigastric distress, abnormal LFTS, reversible alopecia has been observed with the use of Albendazole.

Contraindications

Worm zap is contraindicated in individuals with a known history of hypersensitivity to albendazole or excipients, and in pregnant women. Albendazole is known to be teratogenic and embryotoxic in animals.

Special Precautions

Worm zap should be used with caution in individuals with evidence of hepatic or renal dysfunction, neurocysticercosis patients should receive appropriate steroid and anticonvulsant therapy.
The drug should be used with caution in nursing women, as the safety is not established.

Praziquantel 

Efficiency of Albendazole is enhanced.

Cimetidine

Albendazole sulphoxide concentration in bile and cystic fluid increases two-fold in hydatid cyst disease.

 Use in Pregnancy

Pregnant women should consult a doctor before taking WORMZAP Suspension or Tablet
Pharmacokinetics: Absorption of Albendazole from the gastrointestinal tract is poor but may be enhanced by a fatty meal. Albendazole rapidly undergoes extensive first-pass metabolism. Its principal metabolite albendazole sulphoxide has anthelmintic activity and a plasma half-life of about 8.5 hours. Albendazole sulphoxide is widely distributed throughout the body including into the bile and the CSF. It is about 70% bound to plasma protein. Albendazole sulphoxide is eliminated in the bile; only a small amount appears to be excreted in the urine.

Storage

Store in a cool dry place below 30°C. Protect from light.

Warning

It has been noted that leucopenia has occurred when used for periods longer than recommended.

KEEP ALL MEDICINES AWAY FROM CHILDREN

Presentation

Bottle of 20ml
400mg tablet in blister pack strip pf 1 tablet and packs of 25x1 tablets.

Shelf-Life
Tablet: 3 years from the date of manufacture.

Suspension: 2 years from the date of manufacture.

Manufactured by:
GR Industries Ltd.
15/5 Valco Road. Heavy Industrial Area,Tema-Ghana.
Tel: 0244313080