Please read leaflet carefully because it contains important information for you. If you have further question, please ask your doctor or pharmacist.
COMPOSITION
Each Capsule Contains
| Ingredient | Strength |
|---|---|
| Iron (III) hydroxide Polymaltose complex Equivalent to Elemental iron | 100 mg |
| Folic Acid BP | 1 mg |
| Vitamin B12 BP | 5 mcg |
| Zinc Sulphate Monohydrate USP | 15 mg |
| Pyridoxine HCl BP | 1.5 mg |
| Ascorbic Acid BP | 100 mg |
Each 5 ml contains
| Ingredient | Strength |
|---|---|
| Iron (III) hydroxide Polymaltose complex Equivalent to Elemental iron | 50 mg |
| Folic Acid BP | 500 mcg |
| Vitamin B12 BP | 7.5 mcg |
| Zinc Sulphate Monohydrate USP | 11 mg |
EXCIPIENTS
CAPSULES
Aerosil
Anhydrous lactose
Magnesium Stearate
SYRUP
Sugar
Liquid glucose
Sodium Hydrochloride
Methyl Paraben Sodium
Propyl Paraben Sodium
Disodium Edetate
Sodium Metabisulphate
Citric Monohydrate
Sodium Citrate
Glycerine
Caramel
Vanilla Flavour
Butterscotch Flavour
Strawberry Flavour
PHARMACOLOGICAL PROPERTIES
X'Feron contains the new generation hematini, Iron (III) hydroxide Polymaltose complex which is superior to iron salt such as ferrous sulphate and fumarate.
Iron Polymaltose is a non-ionic polynuclear ferric hydroxide complex which is extremely well tolerated by the body and hence overcomes the adverse side effects associated with traditional ferrous salts therapy.
There is a minimal gastro-intestinal side effect, incidence of constipation, diarrhea, nausea and vomiting.
It does not cause iron overloading but rather causes a significant rise in haemoglobin value.
PHARMACODYNAMICS
X'Feron is a haematinic preparation containing Iron (III) hydroxide Polymaltose complex, Folic acid, Zinc sulphate, Vitamin B6, Vitamin B12.
Iron is an important part of haemoglobin in red blood cells and myoglobin in muscle cells.
It forms a component of body enzymes and proteins.
Iron is useful for immune functions and is an agent for drug detoxification.
Folic acid is essential in the synthesis of nucleoprotein and red blood cell maturation.
Vitamin B12 is required to convert folate coenzymes to the active forms which are needed for important metabolic reactions and essential for normal functioning of cell metabolism especially in the gastrointestinal, Bone marrow and nervous tissues.
Zinc sulphate is an essential compound of proteins, fat and carbohydrate metabolism and is also required for osteoblastic activity and formation of bone marrow.
Zinc is an important constituent of enzymes and its deficiency leads to impaired wound healing and growth retardation.
Vitamin B6 (Pyridoxine) influences hemoglobin formation.
It also plays an important role in chemical reaction as well as formation of hormones.
Ascorbic acid, an important antioxidant promotes iron absorption from Gastro-intestinal Tract and helps in haemoglobin formation.
It is required for maintaining healthy blood vessels, gum and teeth.
Vitamin C contributes to wound healing and fracture repair.
INDICATIONS
X'Feron is indicated for the treatment of:
Iron deficiency anemia
Megaloblastic anaemia
Pregnancy anemia
Post-operative convalescence
Anaemia in geriatric patients
Prevention of iron deficiency before, during and after pregnancy and during breast feeding
It is also used as a supplementary therapy in disease states that can results in anaemia.
DOSAGE AND ADMINISTRATION
SYRUP
Adults and children over 10 years:
10 ml once daily.
Children aged 2–10 years:
5 ml once daily.
CAPSULE
Therapeutic:
One Capsule two times daily after food or as prescribed by a physician.
Prophylactic:
One capsule daily after food.
SIDE EFFECTS
X'Feron is generally well tolerated.
However a few side effects of oral iron preparations such as:
Nausea
Vomiting
Constipation
Diarrhea
may occur in a few patients.
It may cause:
Convulsions
Hypoglycaemia
Occasionally jaundice
Colours stool black
Other side effects can occur due to allergic reaction to any of the active ingredients or excipients.
These may include:
Rash
Itching
Swelling
Dizziness
Trouble breathing
If you notice these or other effects not mentioned above, stop taking this medicine and contact your doctor or pharmacist immediately.
PRECAUTIONS
X'Feron should not be taken on an empty stomach and should not be given with hot food.
To prevent iron toxicity care should be taken when X'Feron is given to patients with haemoglobinopathies or existing Gastro-intestinal Tract disease.
X'Feron should not be given concomitantly with:
Tetracyclines
Antacids
Chloramphenicol
CONTRAINDICATIONS
Hypersensitivity to any of the ingredients in the formula.
PREGNANCY AND LACTATION
Talk to your doctor or Pharmacist.
DRUG INTERACTIONS
X'Feron may affect or be affected by other medicines.
Consult your doctor or pharmacist before using X'Feron if you are taking any of the following medicines:
Tetracycline or quinolone antibiotics
Antacids
H2 blockers
Proton pump inhibitors
Carbamazepine
Phenytoin
Non-steroidal anti-inflammatory drugs
Sulphasalazine
Triamterene
Birth control pills
Methotrexate
Cholestyramine
Colestipol
Amiloride
ACE inhibitors
Cisplatin
Corticosteroids
Cyclosporine
Penicillamine
Thiazide diuretics
Cimetidine
Para-aminosalicylic acid
Neomycin
Potassium chloride
Biguanides
Methyldopa
OVERDOSAGE
In case of overdose, neither intoxication nor iron overload have been reported.
However, it is recommended to contact your doctor or pharmacist immediately in case of overdose.
STORAGE
Do not store above 30°C.
Keep out of the sight and reach of children.
PMI046
PRESENTATION
Pack of 200 ml and 150 ml bottle
3 × 10 capsules per pack
DATE OF PUBLICATION
2023
DATE OF REVIEW
2028
Manufactured by
ENTRANCE PHARMACEUTICALS & RESEARCH CENTRE
No. 16 Okpoi Gonno Spintex Road
Accra-Ghana
ISO 9001 Certified Company